4oo5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of S-nitrosated Human Thioredoxin Mutant===

~~The entry 4oo5 is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>

~~Authors~~: ~~The, J~~.~~, Weichsel, A~~.~~, Montfort, W~~.R.

==About this Structure==

[[4oo5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO5 OCA].

~~Description~~: ~~Crystal Structure of~~ S-~~nitrosated Human Thioredoxin Mutant~~

==Reference==

[[Category: Montfort, W R.]]

[[Category: The, J.]]

[[Category: Weichsel, A.]]

[[Category: Oxidoreductase]]

[[Category: S-nitrosation]]

[[Category: S-nitrosocysteine]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4oo5|  PDB=4oo5  |  SCENE=  }}
+===Crystal Structure of S-nitrosated Human Thioredoxin Mutant===
+{{ABSTRACT_PUBMED_20662007}}
-The entry 4oo5 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>   ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
-Authors: The, J., Weichsel, A., Montfort, W.R.
+==About this Structure==
+[[4oo5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO5 OCA].
-Description: Crystal Structure of S-nitrosated Human Thioredoxin Mutant
+==Reference==
+<ref group="xtra">PMID:020662007</ref><references group="xtra"/><references/>
+[[Category: Montfort, W R.]]
+[[Category: The, J.]]
+[[Category: Weichsel, A.]]
+[[Category: Oxidoreductase]]
+[[Category: S-nitrosation]]
+[[Category: S-nitrosocysteine]]