3wn4: Difference between revisions
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{{STRUCTURE_3wn4| PDB=3wn4 | SCENE= }} | |||
===Crystal structure of human TLR8 in complex with DS-877=== | |||
{{ABSTRACT_PUBMED_24474703}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | |||
==About this Structure== | |||
[[3wn4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WN4 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024474703</ref><references group="xtra"/><references/> | |||
[[Category: Ohto, U.]] | |||
[[Category: Shimizu, T.]] | |||
[[Category: Tanji, H.]] | |||
[[Category: Antiviral-antitumor drug binding]] | |||
[[Category: Glycosylation]] | |||
[[Category: Immune system]] | |||
[[Category: Innate immunity]] | |||
[[Category: Leucine rich repeat]] | |||
[[Category: Rna]] | |||
[[Category: Rna recognition]] | |||
[[Category: Ssrnar]] | |||
[[Category: Structure-based ligand design]] | |||
[[Category: Tlr8-specific agonist]] | |||
[[Category: Vaccine adjuvant]] | |||
Revision as of 17:37, 19 February 2014
Crystal structure of human TLR8 in complex with DS-877
Template:ABSTRACT PUBMED 24474703
Function
[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]
About this Structure
3wn4 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Kokatla HP, Sil D, Tanji H, Ohto U, Malladi SS, Fox LM, Shimizu T, David SA. Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists. ChemMedChem. 2014 Jan 28. doi: 10.1002/cmdc.201300573. PMID:24474703 doi:https://dx.doi.org/10.1002/cmdc.201300573
- ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200
