4o7d: Difference between revisions
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{{STRUCTURE_4o7d| PDB=4o7d | SCENE= }} | |||
===Crystal structure of human glutaminase in complex DON=== | |||
{{ABSTRACT_PUBMED_24451979}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | |||
==About this Structure== | |||
[[4o7d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7D OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024451979</ref><references group="xtra"/><references/> | |||
[[Category: Glutaminase]] | |||
[[Category: Sivaraman, J.]] | |||
[[Category: Thangavelu, K.]] | |||
[[Category: Hydrolase]] | |||
Revision as of 09:48, 16 April 2014
Crystal structure of human glutaminase in complex DON
Template:ABSTRACT PUBMED 24451979
Function
[GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
About this Structure
4o7d is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Thangavelu K, Chong QY, Low BC, Sivaraman J. Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827. PMID:24451979 doi:https://dx.doi.org/10.1038/srep03827
