4m0q: Difference between revisions

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~~'''Unreleased~~ structure~~'''~~

===Ebola virus VP24 structure===

~~The entry 4m0q is ON HOLD~~ ~~until Aug 01 2015~~

==Function==

[[http://www.uniprot.org/uniprot/VP24_EBOZM VP24_EBOZM]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.<ref>PMID:12191476</ref> <ref>PMID:12525613</ref> <ref>PMID:15220407</ref> <ref>PMID:17928350</ref>

~~Authors~~: ~~Xu, W., Leung, D.W~~.~~, Borek, D~~.~~, Amarasinghe, G~~.K.

==About this Structure==

[[4m0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0Q OCA].

~~Description~~: Ebola virus ~~VP24 structure~~

==Reference==

[[Category: Amarasinghe, G K.]]

[[Category: Borek, D.]]

[[Category: Leung, D W.]]

[[Category: Xu, W.]]

[[Category: Ebola virus virulence factor]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m0q|  PDB=4m0q  |  SCENE=  }}
+===Ebola virus VP24 structure===
-The entry 4m0q is ON HOLD  until Aug 01 2015
+==Function==
+[[http://www.uniprot.org/uniprot/VP24_EBOZM VP24_EBOZM]] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.<ref>PMID:12191476</ref> <ref>PMID:12525613</ref> <ref>PMID:15220407</ref> <ref>PMID:17928350</ref>
-Authors: Xu, W., Leung, D.W., Borek, D., Amarasinghe, G.K.
+==About this Structure==
+[[4m0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0Q OCA].
-Description: Ebola virus VP24 structure
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Amarasinghe, G K.]]
+[[Category: Borek, D.]]
+[[Category: Leung, D W.]]
+[[Category: Xu, W.]]
+[[Category: Ebola virus virulence factor]]
+[[Category: Viral protein]]