4cq1: Difference between revisions
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New page: {{STRUCTURE_4cq1| PDB=4cq1 | SCENE= }} ===Crystal structure of the neuronal isoform of PTB=== ==Function== http://www.uniprot.org/uniprot/PTBP2_HUMAN PTBP2_HUMAN RNA-binding prot... |
m Protected "4cq1" [edit=sysop:move=sysop] |
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Revision as of 17:12, 19 February 2014
Crystal structure of the neuronal isoform of PTB
Function
[PTBP2_HUMAN] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.[1] [2]
About this Structure
4cq1 is a 8 chain structure. This structure supersedes the now removed PDB entry 4cko. Full crystallographic information is available from OCA.
Reference
- ↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol. 2000 Oct;20(20):7463-79. PMID:11003644
- ↑ Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell. 2003 Mar;11(3):757-71. PMID:12667457
