3tmk: Difference between revisions

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[[Image:3tmk.gif|left|200px]]<br /><applet load="3tmk" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3tmk.gif|left|200px]]
caption="3tmk, resolution 2.0&Aring;" />
 
'''CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION'''<br />
{{Structure
|PDB= 3tmk |SIZE=350|CAPTION= <scene name='initialview01'>3tmk</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=T5A:P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE'>T5A</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
3TMK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=T5A:'>T5A</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TMK OCA].  
3TMK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TMK OCA].  


==Reference==
==Reference==
Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation., Lavie A, Konrad M, Brundiers R, Goody RS, Schlichting I, Reinstein J, Biochemistry. 1998 Mar 17;37(11):3677-86. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9521686 9521686]
Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation., Lavie A, Konrad M, Brundiers R, Goody RS, Schlichting I, Reinstein J, Biochemistry. 1998 Mar 17;37(11):3677-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9521686 9521686]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: phosphotransferase]]
[[Category: phosphotransferase]]


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