Filamin: Difference between revisions
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[[Filamin]] '''A (FLNA)''' has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development. '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain. For more details on filaminC see [[Group:MUZIC:FilaminC]]. The images at the left and at the right correspond to one representative filamin structure, ''i.e.'' the crystal structure of human filamin A ([[3hop]]), it forms a <scene name='Filamin/Cv/2'>dimer</scene> <ref>PMID:19773341</ref>. Two phosphate ions are rendered as space filling objects. | * [[Filamin]] '''A (FLNA)''' has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.<br /> | ||
* '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development.<br /> | |||
* '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain.<br /> | |||
For more details on filaminC see [[Group:MUZIC:FilaminC]]. The images at the left and at the right correspond to one representative filamin structure, ''i.e.'' the crystal structure of human filamin A ([[3hop]]), it forms a <scene name='Filamin/Cv/2'>dimer</scene> <ref>PMID:19773341</ref>. Two phosphate ions are rendered as space filling objects. | |||
===3D structures of filamin=== | ===3D structures of filamin=== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
== Filamin A == | === Filamin A === | ||
[[3isw]] – hFLNA repeat 21+CFTR peptide – human<br /> | [[3isw]] – hFLNA repeat 21+CFTR peptide – human<br /> | ||
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[[3cnk]] - hFLNA DD<br /> | [[3cnk]] - hFLNA DD<br /> | ||
== Filamin B == | === Filamin B === | ||
[[2wa5]], [[3fer]], [[2eea]] - hFLNB ABD<br /> | [[2wa5]], [[3fer]], [[2eea]] - hFLNB ABD<br /> | ||
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[[2di9]], [[2dia]], [[2dib]], [[2dic]], [[2dj4]], [[2e9j]], [[2dmb]], [[2ee9]], [[2ee7]], [[2dmc]], [[2di8]], [[2dlg]], [[2e9i]], [[2ee6]], [[2eeb]], [[2eec]], [[2eed]] - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR<br /> | [[2di9]], [[2dia]], [[2dib]], [[2dic]], [[2dj4]], [[2e9j]], [[2dmb]], [[2ee9]], [[2ee7]], [[2dmc]], [[2di8]], [[2dlg]], [[2e9i]], [[2ee6]], [[2eeb]], [[2eec]], [[2eed]] - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR<br /> | ||
== Filamin C == | === Filamin C === | ||
[[2k9u]] – hFLNC+migfilin peptide<br /> | [[2k9u]] – hFLNC+migfilin peptide<br /> | ||
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[[1v05]] - hFLNC DD<br /> | [[1v05]] - hFLNC DD<br /> | ||
== Other Filamins == | === Other Filamins === | ||
[[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br /> | [[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br /> | ||
Revision as of 08:34, 18 August 2014
- Filamin A (FLNA) has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
- Filamin B (FLNB) is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development.
- Filamin C (FLNC) is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain.
For more details on filaminC see Group:MUZIC:FilaminC. The images at the left and at the right correspond to one representative filamin structure, i.e. the crystal structure of human filamin A (3hop), it forms a dimer [1]. Two phosphate ions are rendered as space filling objects.
3D structures of filamin
Updated on 18-August-2014
Filamin A
3isw – hFLNA repeat 21+CFTR peptide – human
3rgh - hFLNA repeat 10
2wfn, 3hop, 3hor – hFLNA ABD
3hoc – hFLNA ABD (mutant)
4m9p - hFLNA domains 3-5
2aav - hFLNA domain 17 – NMR
2bp3 - hFLNA domain 17+GPIB peptide
2k7p – hFLNA domains 16-17
2k7q - hFLNA domains 18-19
2j3s - hFLNA domains 19-21
2w0p - hFLNA domain 21+migfilin peptide
2jf1, 2brq - hFLNA domain 21+integrin peptide
2k3t - hFLNA domain 23 – NMR
3cnk - hFLNA DD
Filamin B
2wa5, 3fer, 2eea - hFLNB ABD
2wa6, 2wa7, 4b7l - hFLNB ABD (mutant)
2di9, 2dia, 2dib, 2dic, 2dj4, 2e9j, 2dmb, 2ee9, 2ee7, 2dmc, 2di8, 2dlg, 2e9i, 2ee6, 2eeb, 2eec, 2eed - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR
Filamin C
2k9u – hFLNC+migfilin peptide
2d7m, 2d7n, 2d7o, 2d7p - hFLNC domains 14, 16, 17, 22 - NMR
2nqc - hFLNC domain 21
2d7q - hFLNC domain 23 – NMR
3v8o - hFLNC domains 4,5
4mgx - hFLNC domains 4,5 + platelet glycoprotein peptide
1v05 - hFLNC DD
Other Filamins
1wlh, 1qfh – FLN rod domain – Dictyostelium discoideum
References
- ↑ Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009 Dec 15;18(24):4791-800. Epub 2009 Sep 22. PMID:19773341 doi:10.1093/hmg/ddp442
