Fructokinase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3lki| PDB=3lki | SIZE=400| SCENE= |right|CAPTION=Se-Met fructokinase dimer complex with ATP (stick model), phosphate and K+ ion (purple), [[3lki]] }} | {{STRUCTURE_3lki| PDB=3lki | SIZE=400| SCENE= |right|CAPTION=Se-Met fructokinase dimer complex with ATP (stick model), phosphate and K+ ion (purple), [[3lki]] }} | ||
== Function == | |||
'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>. | |||
== Relevance == | |||
Inhibitors of FRK C may block sugar-associated metabolic syndromes. | |||
'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors. | |||
== Disease == | |||
FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria<ref>PMID:2992452</ref>. | |||
==3D structures of fructokinase== | ==3D structures of fructokinase== | ||
| Line 20: | Line 24: | ||
[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br /> | [[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br /> | ||
[[3c8u]] – FRK – ''Silicibacter''<br /> | [[3c8u]] – FRK – ''Silicibacter''<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:03, 2 March 2016
Function
Fructokinase (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors[1].
Relevance
Inhibitors of FRK C may block sugar-associated metabolic syndromes.
Disease
FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria[2].
3D structures of fructokinase
Updated on 02-March-2016
2qhp – FRK – Bacterioides thetaiotamicron
3ljs – XfFRK – Xylella fastidiosa
3hj6 – FRK – Halothermothrix orenii
3lki – XfFRK + ATP
3lm9 - BsFRK + ATP + fructose – Bacillus subtilis
3ohr - BsFRK + ADP
2v78, 2var – FRK – Sulfolobus solfataricus
3c8u – FRK – Silicibacter
References
- ↑ James HM, Williams SG, Bais R, Rofe AM, Edwards JB, Conyers RA. The metabolic production of oxalate from xylitol: activities of transketolase, transaldolase, fructokinase and aldolase in liver, kidney, brain, heart and muscle in the rat, mouse, guinea pig, rabbit and human. Int J Vitam Nutr Res Suppl. 1985;28:29-46. PMID:3009653
- ↑ Phillips MI, Davies DR. The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase. Biochem J. 1985 Jun 15;228(3):667-71. PMID:2992452
