Fibronectin: Difference between revisions
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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | ||
{{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions [[3m7p]] }} | {{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) [[3m7p]] }} | ||
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[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | [[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | ||
== 3D Structures of Fibronectin == | == 3D Structures of Fibronectin == | ||
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[[2fn2]] – hFn 2FnII – NMR | [[2fn2]] – hFn 2FnII – NMR | ||
=== Fn module FnIII === | === Fn module FnIII === | ||
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[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br /> | [[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br /> | ||
[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens'' | [[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens'' | ||
=== Fn module FnI+FnII === | === Fn module FnI+FnII === | ||
