4cqo: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "4cqo" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4cqo| PDB=4cqo | SCENE= }} | |||
===Structure of the human CNOT1 superfamily homology domain in complex with a Nanos1 peptide=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/NANO1_HUMAN NANO1_HUMAN]] Male infertility due to NANOS1 mutation. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/NANO1_HUMAN NANO1_HUMAN]] May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.<ref>PMID:17047063</ref> <ref>PMID:18223680</ref> | |||
==About this Structure== | |||
[[4cqo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQO OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Bhandari, D.]] | |||
[[Category: Izaurralde, E.]] | |||
[[Category: Jonas, S.]] | |||
[[Category: Raisch, T.]] | |||
[[Category: Weichenrieder, O.]] | |||
[[Category: Deadenylation]] | |||
[[Category: Development]] | |||
[[Category: Gene regulation]] | |||
[[Category: Protein complex]] | |||
[[Category: Short linear motif]] | |||
[[Category: Translation]] | |||
[[Category: Translational repression]] | |||
Revision as of 07:51, 23 April 2014
Structure of the human CNOT1 superfamily homology domain in complex with a Nanos1 peptide
Disease
[NANO1_HUMAN] Male infertility due to NANOS1 mutation. The disease is caused by mutations affecting the gene represented in this entry.
Function
[CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.[1] [2] [NANO1_HUMAN] May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.[3] [4]
About this Structure
4cqo is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000 Feb 1;28(3):809-17. PMID:10637334
- ↑ Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15. PMID:16778766 doi:7601194
- ↑ Strumane K, Bonnomet A, Stove C, Vandenbroucke R, Nawrocki-Raby B, Bruyneel E, Mareel M, Birembaut P, Berx G, van Roy F. E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. Cancer Res. 2006 Oct 15;66(20):10007-15. PMID:17047063 doi:https://dx.doi.org/10.1158/0008-5472.CAN-05-3096
- ↑ Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, Berx G, van Roy F, Birembaut P, Nawrocki-Raby B. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. Oncogene. 2008 Jun 12;27(26):3692-9. doi: 10.1038/sj.onc.1211035. Epub 2008 Jan, 28. PMID:18223680 doi:https://dx.doi.org/10.1038/sj.onc.1211035
