4nm7: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif===

~~The~~ entry ~~4nm7~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/AXIN1_HUMAN AXIN1_HUMAN]] Defects in AXIN1 are involved in hepatocellular carcinoma (HCC) [MIM:[http://omim.org/entry/114550 114550]].<ref>PMID:10700176</ref> <ref>PMID:12101426</ref> Defects in AXIN1 are a cause of caudal duplication anomaly (CADUA) [MIM:[http://omim.org/entry/607864 607864]]. Caudal duplication anomaly is characterized by the occurrence of duplications of different organs in the caudal region. Note=Caudal duplication anomaly is associated with hypermethylation of the AXIN1 promoter.<ref>PMID:10700176</ref>

~~Authors~~: ~~Stamos, J~~.L., ~~Chu~~, ~~M.L.~~-H., ~~Enos, M~~.D.~~, Shah, N~~., ~~Weis, W.I~~.

==Function==

[[http://www.uniprot.org/uniprot/AXIN1_HUMAN AXIN1_HUMAN]] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.<ref>PMID:12192039</ref> <ref>PMID:16601693</ref> <ref>PMID:17210684</ref>

~~Description~~:

==About this Structure==

[[4nm7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM7 OCA].

==Reference==

[[Category: Chu, M L.H.]]

[[Category: Enos, M D.]]

[[Category: Shah, N.]]

[[Category: Stamos, J L.]]

[[Category: Weis, W I.]]

[[Category: Auto-inhibited]]

[[Category: Axin]]

[[Category: Gsk-3]]

[[Category: Kinase]]

[[Category: Lrp6]]

[[Category: Phosphorylated wnt receptor lrp6 e-motif]]

[[Category: Primed substrate]]

[[Category: Transferase-peptide complex]]

[[Category: Wnt]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nm7|  PDB=4nm7  |  SCENE=  }}
+===Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif===
-The entry 4nm7 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/AXIN1_HUMAN AXIN1_HUMAN]] Defects in AXIN1 are involved in hepatocellular carcinoma (HCC) [MIM:[http://omim.org/entry/114550 114550]].<ref>PMID:10700176</ref> <ref>PMID:12101426</ref>   Defects in AXIN1 are a cause of caudal duplication anomaly (CADUA) [MIM:[http://omim.org/entry/607864 607864]]. Caudal duplication anomaly is characterized by the occurrence of duplications of different organs in the caudal region. Note=Caudal duplication anomaly is associated with hypermethylation of the AXIN1 promoter.<ref>PMID:10700176</ref>
-Authors: Stamos, J.L., Chu, M.L.-H., Enos, M.D., Shah, N., Weis, W.I.
+==Function==
+[[http://www.uniprot.org/uniprot/AXIN1_HUMAN AXIN1_HUMAN]] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.<ref>PMID:12192039</ref> <ref>PMID:16601693</ref> <ref>PMID:17210684</ref>
-Description:
+==About this Structure==
+[[4nm7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM7 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Chu, M L.H.]]
+[[Category: Enos, M D.]]
+[[Category: Shah, N.]]
+[[Category: Stamos, J L.]]
+[[Category: Weis, W I.]]
+[[Category: Auto-inhibited]]
+[[Category: Axin]]
+[[Category: Gsk-3]]
+[[Category: Kinase]]
+[[Category: Lrp6]]
+[[Category: Phosphorylated wnt receptor lrp6 e-motif]]
+[[Category: Primed substrate]]
+[[Category: Transferase-peptide complex]]
+[[Category: Wnt]]