4nv0: Difference between revisions
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{{STRUCTURE_4nv0| PDB=4nv0 | SCENE= }} | |||
===Crystal structure of cytosolic 5'-nucleotidase IIIB (cN-IIIB) bound to 7-methylguanosine=== | |||
{{ABSTRACT_PUBMED_24603684}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/5NT3B_DROME 5NT3B_DROME]] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates. | |||
==About this Structure== | |||
[[4nv0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NV0 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024603684</ref><references group="xtra"/><references/> | |||
[[Category: 5'-nucleotidase]] | |||
[[Category: Ficner, R.]] | |||
[[Category: Monecke, T.]] | |||
[[Category: Neumann, P.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Rossmannoid fold]] | |||