4cla: Difference between revisions

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[[Image:4cla.gif|left|200px]]<br /><applet load="4cla" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:4cla.gif|left|200px]]
caption="4cla, resolution 2.0&Aring;" />
 
'''ALTERNATIVE BINDING MODES FOR CHLORAMPHENICOL AND 1-SUBSTITUTED CHLORAMPHENICOL ANALOGUES REVEALED BY SITE-DIRECTED MUTAGENESIS AND X-RAY CRYSTALLOGRAPHY OF CHLORAMPHENICOL ACETYLTRANSFERASE'''<br />
{{Structure
|PDB= 4cla |SIZE=350|CAPTION= <scene name='initialview01'>4cla</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene> and <scene name='pdbligand=CLM:CHLORAMPHENICOL'>CLM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Chloramphenicol_O-acetyltransferase Chloramphenicol O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.28 2.3.1.28]
|GENE=
}}
 
'''ALTERNATIVE BINDING MODES FOR CHLORAMPHENICOL AND 1-SUBSTITUTED CHLORAMPHENICOL ANALOGUES REVEALED BY SITE-DIRECTED MUTAGENESIS AND X-RAY CRYSTALLOGRAPHY OF CHLORAMPHENICOL ACETYLTRANSFERASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
4CLA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=CO:'>CO</scene> and <scene name='pdbligand=CLM:'>CLM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Chloramphenicol_O-acetyltransferase Chloramphenicol O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.28 2.3.1.28] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLA OCA].  
4CLA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLA OCA].  


==Reference==
==Reference==
Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase., Murray IA, Lewendon A, Williams JA, Cullis PM, Shaw WV, Leslie AG, Biochemistry. 1991 Apr 16;30(15):3763-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2015231 2015231]
Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase., Murray IA, Lewendon A, Williams JA, Cullis PM, Shaw WV, Leslie AG, Biochemistry. 1991 Apr 16;30(15):3763-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2015231 2015231]
[[Category: Chloramphenicol O-acetyltransferase]]
[[Category: Chloramphenicol O-acetyltransferase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: transferase (acyltransferase)]]
[[Category: transferase (acyltransferase)]]


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