4po6: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide===

~~The~~ entry ~~4po6 is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

~~Authors~~: ~~Wallweber, H~~.J.A., ~~Lupardus~~, ~~P.J~~.

==Function==

[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> [[http://www.uniprot.org/uniprot/INAR1_HUMAN INAR1_HUMAN]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

~~Description~~: ~~Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide~~

==About this Structure==

[[4po6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PO6 OCA].

==Reference==

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Lupardus, P J.]]

[[Category: Wallweber, H J.A.]]

[[Category: Cytokine]]

[[Category: Ferm]]

[[Category: Intracellular]]

[[Category: Kinase]]

[[Category: Receptor]]

[[Category: Sh2]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4po6|  PDB=4po6  |  SCENE=  }}
+===Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide===
-The entry 4po6 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
-Authors: Wallweber, H.J.A., Lupardus, P.J.
+==Function==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>  [[http://www.uniprot.org/uniprot/INAR1_HUMAN INAR1_HUMAN]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
-Description: Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide
+==About this Structure==
+[[4po6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PO6 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Lupardus, P J.]]
+[[Category: Wallweber, H J.A.]]
+[[Category: Cytokine]]
+[[Category: Ferm]]
+[[Category: Intracellular]]
+[[Category: Kinase]]
+[[Category: Receptor]]
+[[Category: Sh2]]
+[[Category: Transferase]]