2mij: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==NMR structure of the S-linked glycopeptide sublancin 168== | |||
<StructureSection load='2mij' size='340' side='right' caption='[[2mij]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIJ FirstGlance]. <br> | |||
==Function== | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mij OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mij RCSB], [http://www.ebi.ac.uk/pdbsum/2mij PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SUNA_BACSU SUNA_BACSU]] Bacteriocin active against Gram-positive bacteria. Inhibits B.cereus spore outgrowth, after the germination stage, approximately 1000-fold better than it inhibits exponential growth of the same cells. Inhibits B.subtilis strain ATCC 6633.<ref>PMID:21196935</ref> | [[http://www.uniprot.org/uniprot/SUNA_BACSU SUNA_BACSU]] Bacteriocin active against Gram-positive bacteria. Inhibits B.cereus spore outgrowth, after the germination stage, approximately 1000-fold better than it inhibits exponential growth of the same cells. Inhibits B.subtilis strain ATCC 6633.<ref>PMID:21196935</ref> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Sublancin 168 is a member of a small group of glycosylated antimicrobial peptides known as glycocins. The solution structure of sublancin 168, a 37-amino-acid peptide produced by Bacillus subtilis 168, has been solved by nuclear magnetic resonance (NMR) spectroscopy. Sublancin comprises two alpha-helices and a well-defined interhelical loop. The two helices span residues 6-16 and 26-35, and the loop region encompasses residues 17-25. The 9-amino-acid loop region contains a beta-S-linked glucose moiety attached to Cys22. Hydrophobic interactions as well as hydrogen bonding are responsible for the well-structured loop region. The three-dimensional structure provides an explanation for the previously reported extraordinary high stability of sublancin 168. | |||
NMR Structure of the S-Linked Glycopeptide Sublancin 168.,Garcia De Gonzalo CV, Zhu L, Oman TJ, van der Donk WA ACS Chem Biol. 2014 Jan 17. PMID:24405370<ref>PMID:24405370</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Donk, W A.van der | [[Category: Donk, W A.van der]] | ||
[[Category: Gonzalo, C V.Garcia De | [[Category: Gonzalo, C V.Garcia De]] | ||
[[Category: Oman, T J | [[Category: Oman, T J]] | ||
[[Category: Zhu, L | [[Category: Zhu, L]] | ||
[[Category: Antimicrobial protein]] | [[Category: Antimicrobial protein]] | ||
[[Category: Glycopeptide]] | [[Category: Glycopeptide]] | ||
Revision as of 06:11, 25 December 2014
NMR structure of the S-linked glycopeptide sublancin 168
| ||||||||||||
