3w7r: Difference between revisions
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==Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097== | |||
<StructureSection load='3w7r' size='340' side='right' caption='[[3w7r]], [[Resolution|resolution]] 1.68Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[3w7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W7R FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W7A:2,6-DIOXO-5-[2-(4-PHENYLPHENYL)ETHYL]-1,2,3,6-+TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7A</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w71|3w71]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w7r RCSB], [http://www.ebi.ac.uk/pdbsum/3w7r PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref> | ||
== Function == | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | [[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
<references | [[Category: Aoki, T]] | ||
[[Category: Aoki, T | [[Category: Balogun, E O]] | ||
[[Category: Balogun, E O | [[Category: Harada, S]] | ||
[[Category: Harada, S | [[Category: Hashimoto, S]] | ||
[[Category: Hashimoto, S | [[Category: Honma, T]] | ||
[[Category: Honma, T | [[Category: Iida, M]] | ||
[[Category: Iida, M | [[Category: Inaoka, D K]] | ||
[[Category: Inaoka, D K | [[Category: Inoue, M]] | ||
[[Category: Inoue, M | [[Category: Kita, K]] | ||
[[Category: Kita, K | [[Category: Kuranaga, T]] | ||
[[Category: Kuranaga, T | [[Category: Lee, N]] | ||
[[Category: Lee, N | [[Category: Matsuoka, S]] | ||
[[Category: Matsuoka, S | [[Category: Nara, T]] | ||
[[Category: Nara, T | [[Category: Sakamoto, K]] | ||
[[Category: Sakamoto, K | [[Category: Shiba, T]] | ||
[[Category: Shiba, T | [[Category: Suzuki, S]] | ||
[[Category: Suzuki, S | [[Category: Tabuchi, T]] | ||
[[Category: Tabuchi, T | [[Category: Tanaka, A]] | ||
[[Category: Tanaka, A | |||
[[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]] | [[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]] | ||
[[Category: Mitochondrial inner membrane]] | [[Category: Mitochondrial inner membrane]] | ||
Revision as of 09:32, 4 January 2015
Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Human
- Aoki, T
- Balogun, E O
- Harada, S
- Hashimoto, S
- Honma, T
- Iida, M
- Inaoka, D K
- Inoue, M
- Kita, K
- Kuranaga, T
- Lee, N
- Matsuoka, S
- Nara, T
- Sakamoto, K
- Shiba, T
- Suzuki, S
- Tabuchi, T
- Tanaka, A
- Dihydroorotate/orotate and ubiquinone/ubiquinol
- Mitochondrial inner membrane
- Oxidoreductase
- Oxidoreductase-oxidoreductase inhibitor complex
- Rossmann fold
