4rsd: Difference between revisions

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[[Image:4rsd.jpg|left|200px]]<br /><applet load="4rsd" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:4rsd.jpg|left|200px]]
caption="4rsd, resolution 1.6&Aring;" />
 
'''STRUCTURE OF THE D121A VARIANT OF RIBONUCLEASE A'''<br />
{{Structure
|PDB= 4rsd |SIZE=350|CAPTION= <scene name='initialview01'>4rsd</scene>, resolution 1.6&Aring;
|SITE= <scene name='pdbsite=B1:Pyrimidine+Binding+Site+On+5'+Side+Of+Scissile+Phosphate'>B1</scene>, <scene name='pdbsite=B2:Purine+Binding+Site+On+3'+Side+Of+Scissile+Phosphate'>B2</scene>, <scene name='pdbsite=P1:Catalyzes+Cleavage+Of+P-O5'+Bond+Of+A+Phosphoryl+Group+I+...'>P1</scene> and <scene name='pdbsite=P2:Phosphate+Binding+Site'>P2</scene>
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]
|GENE=
}}
 
'''STRUCTURE OF THE D121A VARIANT OF RIBONUCLEASE A'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
4RSD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Known structural/functional Sites: <scene name='pdbsite=B1:Pyrimidine+Binding+Site+On+5'+Side+Of+Scissile+Phosphate'>B1</scene>, <scene name='pdbsite=B2:Purine+Binding+Site+On+3'+Side+Of+Scissile+Phosphate'>B2</scene>, <scene name='pdbsite=P1:Catalyzes+Cleavage+Of+P-O5'+Bond+Of+A+Phosphoryl+Group+I+...'>P1</scene> and <scene name='pdbsite=P2:Phosphate+Binding+Site'>P2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RSD OCA].  
4RSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RSD OCA].  


==Reference==
==Reference==
His...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes., Schultz LW, Quirk DJ, Raines RT, Biochemistry. 1998 Jun 23;37(25):8886-98. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9636030 9636030]
His...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes., Schultz LW, Quirk DJ, Raines RT, Biochemistry. 1998 Jun 23;37(25):8886-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9636030 9636030]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Pancreatic ribonuclease]]
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[[Category: endonuclease]]
[[Category: endonuclease]]
[[Category: hydrolase]]
[[Category: hydrolase]]
[[Category: ribonuclease a]]
[[Category: ribonuclease some]]
[[Category: site-directed mutagenesis]]
[[Category: site-directed mutagenesis]]
[[Category: x-ray diffraction]]
[[Category: x-ray diffraction]]


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