3td1: Difference between revisions

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~~{{STRUCTURE_3td1| PDB=3td1 | SCENE= }}~~

==Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin==

===Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin===

~~{{ABSTRACT_PUBMED_22110016}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3td1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TD1 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GET:GENETICIN'>GET</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mwl|1mwl]], [[3td0|3td0]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3td1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3td1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3td1 RCSB], [http://www.ebi.ac.uk/pdbsum/3td1 PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.

~~==About this Structure==~~

A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides.,Kondo J Angew Chem Int Ed Engl. 2011 Nov 23. doi: 10.1002/anie.201106084. PMID:22110016<ref>PMID:22110016</ref>

~~[[3td1]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il/oca-bin~~/~~ocashort?id=3TD1 OCA].~~

==~~Reference~~==

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:022110016</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

[[Category: Kondo, J.]]

== References ==

__TOC__

</StructureSection>

[[Category: Kondo, J]]

[[Category: Decoding]]

[[Category: Ribosome]]

[[Category: Rna-antibiotic complex]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3td1|  PDB=3td1  |  SCENE=  }}
+==Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin==
-===Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin===
+<StructureSection load='3td1' size='340' side='right' caption='[[3td1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-{{ABSTRACT_PUBMED_22110016}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3td1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TD1 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GET:GENETICIN'>GET</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mwl|1mwl]], [[3td0|3td0]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3td1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3td1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3td1 RCSB], [http://www.ebi.ac.uk/pdbsum/3td1 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.
-==About this Structure==
+A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides.,Kondo J Angew Chem Int Ed Engl. 2011 Nov 23. doi: 10.1002/anie.201106084. PMID:22110016<ref>PMID:22110016</ref>
-[[3td1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TD1 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:022110016</ref><references group="xtra"/><references/>
+</div>
-[[Category: Kondo, J.]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Kondo, J]]
 [[Category: Decoding]]
 [[Category: Ribosome]]
 [[Category: Rna-antibiotic complex]]