2lyg: Difference between revisions
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==Fuc_TBA== | |||
=== | <StructureSection load='2lyg' size='340' side='right' caption='[[2lyg]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2lyg]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LYG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CF:2-HYDROXYETHYL+6-DEOXY-BETA-L-GALACTOPYRANOSIDE'>1CF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [http://www.ebi.ac.uk/pdbsum/2lyg PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5'-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands. | |||
Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.,Gomez-Pinto I, Vengut-Climent E, Lucas R, Avino A, Eritja R, Gonzalez C, Morales JC Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan, 11. PMID:23315826<ref>PMID:23315826</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Avio, A | == References == | ||
[[Category: Eritja, R | <references/> | ||
[[Category: Gomez-Pinto, I | __TOC__ | ||
[[Category: Gonzalez-Ibaez, C | </StructureSection> | ||
[[Category: Lucas, R | [[Category: Avio, A]] | ||
[[Category: Morales, J | [[Category: Eritja, R]] | ||
[[Category: Vengut-Climent, E | [[Category: Gomez-Pinto, I]] | ||
[[Category: Gonzalez-Ibaez, C]] | |||
[[Category: Lucas, R]] | |||
[[Category: Morales, J]] | |||
[[Category: Vengut-Climent, E]] | |||
[[Category: Carbohydrate-dna interaction]] | [[Category: Carbohydrate-dna interaction]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: G-quadruplex structure]] | [[Category: G-quadruplex structure]] | ||
