Sandbox Reserved 911: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 20: | Line 20: | ||
==Relationship to other proteins== | ==Relationship to other proteins== | ||
The hydrolytic water molecules important to FAAH's function suggest an evolutionary relationship of this hydrolase to other enzymes. The structures of other serine hydrolases also display a catalytic water molecule in their active sites. Because hydrolases that are non-homologous to FAAH also require a water molecule to cleave bonds, we can infer that a functional convergance has developed between amidase signature enzymes (such as FAAH) and other classes of serine proteases. (3LJ6) | The hydrolytic water molecules important to FAAH's function suggest an evolutionary relationship of this hydrolase to other enzymes. The structures of other [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolases] also display a catalytic water molecule in their active sites. Because hydrolases that are non-homologous to FAAH also require a water molecule to cleave bonds, we can infer that a functional convergance has developed between amidase signature enzymes (such as FAAH) and other classes of serine proteases. (3LJ6) | ||
</StructureSection> | </StructureSection> | ||
