4mqw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)===

The entry ~~4mqw~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/FSHR_HUMAN FSHR_HUMAN]] Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:[http://omim.org/entry/233300 233300]]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).<ref>PMID:7553856</ref> <ref>PMID:9851774</ref> <ref>PMID:9769327</ref> <ref>PMID:10551778</ref> <ref>PMID:11889179</ref> <ref>PMID:12571157</ref> <ref>PMID:12915623</ref> Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:[http://omim.org/entry/608115 608115]]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.<ref>PMID:12930927</ref> <ref>PMID:12930928</ref> <ref>PMID:15080154</ref> <ref>PMID:16278261</ref> <ref>PMID:17721928</ref> [[http://www.uniprot.org/uniprot/FSHB_HUMAN FSHB_HUMAN]] Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:[http://omim.org/entry/229070 229070]]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.<ref>PMID:8220432</ref> <ref>PMID:9271483</ref> <ref>PMID:9280841</ref>

~~Authors~~: ~~Jiang, X~~.~~, Liu, H~~.~~, Chen, X~~.~~, He, X~~.

==Function==

[[http://www.uniprot.org/uniprot/FSHR_HUMAN FSHR_HUMAN]] Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. [[http://www.uniprot.org/uniprot/FSHB_HUMAN FSHB_HUMAN]] Stimulates development of follicle and spermatogenesis in the reproductive organs.

~~Description~~: ~~Structure of follicle~~-~~stimulating~~ hormone ~~in complex with the entire ectodomain of its receptor (P31)~~

==About this Structure==

[[4mqw]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQW OCA].

==Reference==

[[Category: Chen, X.]]

[[Category: He, X.]]

[[Category: Jiang, X.]]

[[Category: Liu, H.]]

[[Category: Cystine-knot]]

[[Category: Glycoprotein hormone]]

[[Category: Gpcr]]

[[Category: Leucine-rich repeat]]

[[Category: Signaling protein]]

[[Category: Sulfation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4mqw|  PDB=4mqw  |  SCENE=  }}
+===Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)===
-The entry 4mqw is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/FSHR_HUMAN FSHR_HUMAN]] Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:[http://omim.org/entry/233300 233300]]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).<ref>PMID:7553856</ref> <ref>PMID:9851774</ref> <ref>PMID:9769327</ref> <ref>PMID:10551778</ref> <ref>PMID:11889179</ref> <ref>PMID:12571157</ref> <ref>PMID:12915623</ref>   Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:[http://omim.org/entry/608115 608115]]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.<ref>PMID:12930927</ref> <ref>PMID:12930928</ref> <ref>PMID:15080154</ref> <ref>PMID:16278261</ref> <ref>PMID:17721928</ref>  [[http://www.uniprot.org/uniprot/FSHB_HUMAN FSHB_HUMAN]] Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency (IFSHD) [MIM:[http://omim.org/entry/229070 229070]]. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men.<ref>PMID:8220432</ref> <ref>PMID:9271483</ref> <ref>PMID:9280841</ref>
-Authors: Jiang, X., Liu, H., Chen, X., He, X.
+==Function==
+[[http://www.uniprot.org/uniprot/FSHR_HUMAN FSHR_HUMAN]] Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. [[http://www.uniprot.org/uniprot/FSHB_HUMAN FSHB_HUMAN]] Stimulates development of follicle and spermatogenesis in the reproductive organs.
-Description: Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
+==About this Structure==
+[[4mqw]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQW OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Chen, X.]]
+[[Category: He, X.]]
+[[Category: Jiang, X.]]
+[[Category: Liu, H.]]
+[[Category: Cystine-knot]]
+[[Category: Glycoprotein hormone]]
+[[Category: Gpcr]]
+[[Category: Leucine-rich repeat]]
+[[Category: Signaling protein]]
+[[Category: Sulfation]]