4pw5: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I==

~~The entry~~ 4pw5 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4pw5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PW5 OCA].

~~Authors~~: ~~ZHou~~, T., ~~Xiong~~, J., ~~Wang~~, M., ~~Yang~~, N., Wong, J., ~~Zhu~~, B., Xu. R.M.

</td></tr><tr><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4pw6|4pw6]], [[4pw7|4pw7]]</td></tr>

~~Description~~: ~~structure of UHRF2~~-~~SRA in complex with a 5hmC~~-~~containing DNA,~~ complex I

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pw5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pw5 RCSB], [http://www.ebi.ac.uk/pdbsum/4pw5 PDBsum]</td></tr>

<table>

== Disease ==

[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.

== Function ==

[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.<ref>PMID:12176013</ref> <ref>PMID:15178429</ref> <ref>PMID:14741369</ref> <ref>PMID:15361834</ref> <ref>PMID:21952639</ref> <ref>PMID:23404503</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Wang, M.]]

[[Category: Wong, J.]]

[[Category: Xiong, J.]]

[[Category: Xu, R M.]]

[[Category: Yang, N.]]

[[Category: ZHou, T.]]

[[Category: Zhu, B.]]

[[Category: 5hmc binding]]

[[Category: 5hmc-containing dna]]

[[Category: Hydroxymethylation]]

[[Category: Ligase-dna complex]]

[[Category: Nuclear]]

[[Category: Sra]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I==
+<StructureSection load='4pw5' size='340' side='right' caption='[[4pw5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-The entry 4pw5 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4pw5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PW5 OCA]. <br>
-Authors: ZHou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., Xu. R.M.
+</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pw6|4pw6]], [[4pw7|4pw7]]</td></tr>
-Description: structure of UHRF2-SRA in complex with a 5hmC-containing DNA, complex I
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pw5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pw5 RCSB], [http://www.ebi.ac.uk/pdbsum/4pw5 PDBsum]</span></td></tr>
+<table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.
+== Function ==
+[[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.<ref>PMID:12176013</ref> <ref>PMID:15178429</ref> <ref>PMID:14741369</ref> <ref>PMID:15361834</ref> <ref>PMID:21952639</ref> <ref>PMID:23404503</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Wang, M.]]
+[[Category: Wong, J.]]
+[[Category: Xiong, J.]]
+[[Category: Xu, R M.]]
+[[Category: Yang, N.]]
+[[Category: ZHou, T.]]
+[[Category: Zhu, B.]]
+[[Category: 5hmc binding]]
+[[Category: 5hmc-containing dna]]
+[[Category: Hydroxymethylation]]
+[[Category: Ligase-dna complex]]
+[[Category: Nuclear]]
+[[Category: Sra]]