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| {{STRUCTURE_4beo| PDB=4beo | SCENE= }}
| | REMOVED: The PDB entry 4beo was removed. |
| ===Crystal structure of HLA-A1101 in complex with an azobenzene- containing peptide===
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| ==Disease==
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| [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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| ==Function==
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| [[http://www.uniprot.org/uniprot/1A11_HUMAN 1A11_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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| ==About this Structure==
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| [[4beo]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEO OCA].
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| ==Reference==
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| <references group="xtra"/><references/>
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| [[Category: Grotenbreg, G M.]]
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| [[Category: Lescar, J.]]
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| [[Category: Lim, P Y.]]
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| [[Category: Meijers, R.]]
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| [[Category: Thong, S Y.]]
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| [[Category: Verhelst, S H.]]
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| [[Category: Yap, J W.]]
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| [[Category: Immune system]]
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Latest revision as of 07:34, 23 April 2014
REMOVED: The PDB entry 4beo was removed.
