Sandbox reserved 915: Difference between revisions
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== Catalytic triad == | == Catalytic triad == | ||
MGL has a classic <scene name='58/580298/Catalytic_triad/1'>catalytic triad</scene> that contains Ser-His-Asp ('''figure 1'''). The triad was found using site-directed mutagenesis and this experiment confirmed that these amino acid residues are catalytically essential. The catalytic triad is located in the binding pocket buried at the bottom of it in the oxyanion hole connected by a water molecule. This triad has a natural attraction to Endocannabinoids, specifically 2-arachidonylglycerol (2-AG). 2-AG contributes to brain signals (neurons) to suppress the pain pathways when a patient is feeling depressed or suffering from any type of pain. | MGL has a classic <scene name='58/580298/Catalytic_triad/1'>catalytic triad</scene> that contains Ser-His-Asp ('''figure 1'''). The triad was found using site-directed mutagenesis of each individual residue and this experiment confirmed that these amino acid residues are catalytically essential. The catalytic triad is located in the binding pocket buried at the bottom of it in the oxyanion hole connected by a water molecule. This triad has a natural attraction to Endocannabinoids, specifically 2-arachidonylglycerol (2-AG). 2-AG contributes to brain signals (neurons) to suppress the pain pathways when a patient is feeling depressed or suffering from any type of pain. | ||
[[Image:Catalytic_triad.png|right|200|thumb|'''Figure 1:''' Catalytic Triad of MGL structure]] | [[Image:Catalytic_triad.png|right|200|thumb|'''Figure 1:''' Catalytic Triad of MGL structure]] | ||
====Binding==== | ====Binding==== | ||
