Sandbox Reserved 918: Difference between revisions

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===Binding Pocket===

The specificity of the DPP IV in its ability to discern the proline from other amino acids can be seen in the binding pocket where two glutamates, <scene name='57/573132/1x70_glutamates/1'>Glu205-Glu206</scene> orient the substrate allowing only small residues like proline or alanine to fit. The [http://en.wikipedia.org/wiki/Glutamic_acid glutamates] form a [http://en.wikipedia.org/wiki/Salt_bridge_(protein_and_supramolecular) salt bridge] with the N-terminus, positioning the substrate so that only two amino acids can fit into position for hydrolyses. <ref name="Gorrell">PMID: 15584901</ref> Examples of DPP IV substrates with alanine or proline at their N-terminus are:

The specificity of the DPP IV in its ability to discern the proline from other amino acids can be seen in the binding pocket where two glutamates, <scene name='57/573132/1x70_glutamates/2'>Glu205-Glu206</scene> orient the substrate allowing only small residues like proline or alanine to fit. The [http://en.wikipedia.org/wiki/Glutamic_acid glutamates] form a [http://en.wikipedia.org/wiki/Salt_bridge_(protein_and_supramolecular) salt bridge] with the N-terminus, positioning the substrate so that only two amino acids can fit into position for hydrolyses. <ref name="Gorrell">PMID: 15584901</ref> Examples of DPP IV substrates with alanine or proline at their N-terminus are:

{| class="wikitable" style="text-align:center; width:550px; height:200px;"

|+

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===Medical Relevancy===

<scene name='57/573132/1x70_sitagliptin/1'>Sitagliptin</scene>

<scene name='57/573132/1x70_sitagliptin/2'>Sitagliptin</scene>

===References===

Sandbox Reserved 918: Difference between revisions

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@@ Line 16: / Line 16: @@
 <StructureSection load='1X70' size='350' frame='true' align='right' caption='Biological Dimer of DPP IV' scene='57/573132/1x70_basic_dimer/1'>
 ===Binding Pocket===
-The specificity of the DPP IV in its ability to discern the proline from other amino acids can be seen in the binding pocket where two glutamates, <scene name='57/573132/1x70_glutamates/1'>Glu205-Glu206</scene> orient the substrate allowing only small residues like proline or alanine to fit. The [http://en.wikipedia.org/wiki/Glutamic_acid glutamates] form a [http://en.wikipedia.org/wiki/Salt_bridge_(protein_and_supramolecular) salt bridge] with the N-terminus, positioning the substrate so that only two amino acids can fit into position for hydrolyses. <ref name="Gorrell">PMID: 15584901</ref> Examples of DPP IV substrates with alanine or proline at their N-terminus are:
+The specificity of the DPP IV in its ability to discern the proline from other amino acids can be seen in the binding pocket where two glutamates, <scene name='57/573132/1x70_glutamates/2'>Glu205-Glu206</scene> orient the substrate allowing only small residues like proline or alanine to fit. The [http://en.wikipedia.org/wiki/Glutamic_acid glutamates] form a [http://en.wikipedia.org/wiki/Salt_bridge_(protein_and_supramolecular) salt bridge] with the N-terminus, positioning the substrate so that only two amino acids can fit into position for hydrolyses. <ref name="Gorrell">PMID: 15584901</ref> Examples of DPP IV substrates with alanine or proline at their N-terminus are:
 {| class="wikitable" style="text-align:center; width:550px; height:200px;"
 |+
@@ Line 63: / Line 63: @@
 ===Medical Relevancy===
-<scene name='57/573132/1x70_sitagliptin/1'>Sitagliptin</scene>
+<scene name='57/573132/1x70_sitagliptin/2'>Sitagliptin</scene>
 ===References===
 {{reflist}}