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<~~applet load="1stp" size="300" color="white" frame="true" align="right" spinBox="true"~~ />

[[Image:1eve_Static.png|right|400px]]<br />

<big>Welcome to Proteopedia,</big>

==~~This is a placeholder~~==

The collaborative, 3D encyclopedia of proteins and other molecules.

~~This is a placeholder text to help you get started in~~

===Green links change the 3D image!===

~~placing a Jmol applet on your page. At any time, click~~

<big>''Here's an excerpt from one of our pages:''</big>

~~"Show Preview" at the bottom~~ of ~~this page to see how it goes.~~

~~Replace~~ the ~~PDB id after~~ the ~~load~~=" to ~~load and display~~

The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>'''.

~~another structure.~~

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@@ Line 1: / Line 1: @@
-<applet load="1stp" size="300" color="white" frame="true" align="right" spinBox="true" />
+[[Image:1eve_Static.png|right|400px]]<br />
+<big>Welcome to Proteopedia,</big>
-==This is a placeholder==
+The collaborative, 3D encyclopedia of proteins and other molecules.
-This is a placeholder text to help you get started in
+===Green links change the 3D image!===
-placing a Jmol applet on your page. At any time, click
+<big>''Here's an excerpt from one of our pages:''</big>
-"Show Preview" at the bottom of this page to see how it goes.
-Replace the PDB id after the load=" to load and display
+The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity.  The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite ('''<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>''') of the active site, at the bottom, to the peripheral anionic site ('''<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>'''), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only '''<scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>'''.
-another structure.
+----