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The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><font color='green'>indirectly via solvent molecules</font></b>. | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><font color='green'>indirectly via solvent molecules</font></b>. | ||
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