4o64: Difference between revisions
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{{STRUCTURE_4o64| PDB=4o64 | SCENE= }} | |||
===Zinc fingers of KDM2B=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN]] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref> | |||
==About this Structure== | |||
[[4o64]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Arrowsmith,C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Liu, K.]] | |||
[[Category: Min, J.]] | |||
[[Category: SGC, Structural Genomics Consortium.]] | |||
[[Category: Tempel, W.]] | |||
[[Category: Walker, J R.]] | |||
[[Category: Xu, C.]] | |||
[[Category: Cxxc zinc finger]] | |||
[[Category: Metal binding protein]] | |||
[[Category: Ring zinc finger]] | |||
[[Category: Sgc]] | |||
[[Category: Structural genomic]] | |||
[[Category: Structural genomics consortium]] | |||
Revision as of 10:08, 16 April 2014
Zinc fingers of KDM2B
Function
[KDM2B_HUMAN] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.[1] [2]
About this Structure
4o64 is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y. Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006 Feb 16;439(7078):811-6. Epub 2005 Dec 18. PMID:16362057 doi:https://dx.doi.org/nature04433
- ↑ Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature. 2007 Nov 8;450(7167):309-13. PMID:17994099 doi:https://dx.doi.org/nature06255
