4ol0: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran===

~~The entry 4ol0 is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Primary biliary cirrhosis;Autosomal dominant limb-girdle muscular dystrophy type 1F.

~~Authors~~: ~~Tsirkone, V~~.G., ~~Strelkov~~, ~~S.V~~.

==Function==

[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.<ref>PMID:10366588</ref> <ref>PMID:10713112</ref> <ref>PMID:11517331</ref> <ref>PMID:12628928</ref>

~~Description~~: ~~Crystal structure of transportin~~-~~SR2~~, a karyopherin ~~involved in human disease, in complex with~~ Ran

==About this Structure==

[[4ol0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL0 OCA].

==Reference==

[[Category: Strelkov, S V.]]

[[Category: Tsirkone, V G.]]

[[Category: Active transport]]

[[Category: Human karyopherin]]

[[Category: Nucleus]]

[[Category: Protein transport]]

[[Category: Ran gtp-binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ol0|  PDB=4ol0  |  SCENE=  }}
+===Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran===
-The entry 4ol0 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Primary biliary cirrhosis;Autosomal dominant limb-girdle muscular dystrophy type 1F.
-Authors: Tsirkone, V.G., Strelkov, S.V.
+==Function==
+[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>   Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>  [[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.<ref>PMID:10366588</ref> <ref>PMID:10713112</ref> <ref>PMID:11517331</ref> <ref>PMID:12628928</ref>
-Description: Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran
+==About this Structure==
+[[4ol0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL0 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Strelkov, S V.]]
+[[Category: Tsirkone, V G.]]
+[[Category: Active transport]]
+[[Category: Human karyopherin]]
+[[Category: Nucleus]]
+[[Category: Protein transport]]
+[[Category: Ran gtp-binding protein]]