2rka: Difference between revisions

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[[Image:2rka.jpg|left|200px]]<br /><applet load="2rka" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2rka.jpg|left|200px]]
caption="2rka, resolution 1.950&Aring;" />
 
'''The Structure of rat cytosolic PEPCK in complex with phosphoglycolate'''<br />
{{Structure
|PDB= 2rka |SIZE=350|CAPTION= <scene name='initialview01'>2rka</scene>, resolution 1.950&Aring;
|SITE= <scene name='pdbsite=AC1:Pga+Binding+Site+For+Residue+A+623'>AC1</scene>, <scene name='pdbsite=AC2:Pga+Binding+Site+For+Residue+C+623'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Residue+A+700'>AC3</scene>, <scene name='pdbsite=AC4:Mn+Binding+Site+For+Residue+A+701'>AC4</scene>, <scene name='pdbsite=AC5:Na+Binding+Site+For+Residue+A+702'>AC5</scene>, <scene name='pdbsite=AC6:Mn+Binding+Site+For+Residue+C+700'>AC6</scene>, <scene name='pdbsite=AC7:Mn+Binding+Site+For+Residue+C+701'>AC7</scene> and <scene name='pdbsite=AC8:Na+Binding+Site+For+Residue+C+702'>AC8</scene>
|LIGAND= <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32]
|GENE= Pck1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''The Structure of rat cytosolic PEPCK in complex with phosphoglycolate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2RKA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=PGA:'>PGA</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32] Known structural/functional Sites: <scene name='pdbsite=AC1:Pga+Binding+Site+For+Residue+A+623'>AC1</scene>, <scene name='pdbsite=AC2:Pga+Binding+Site+For+Residue+C+623'>AC2</scene>, <scene name='pdbsite=AC3:Mn+Binding+Site+For+Residue+A+700'>AC3</scene>, <scene name='pdbsite=AC4:Mn+Binding+Site+For+Residue+A+701'>AC4</scene>, <scene name='pdbsite=AC5:Na+Binding+Site+For+Residue+A+702'>AC5</scene>, <scene name='pdbsite=AC6:Mn+Binding+Site+For+Residue+C+700'>AC6</scene>, <scene name='pdbsite=AC7:Mn+Binding+Site+For+Residue+C+701'>AC7</scene> and <scene name='pdbsite=AC8:Na+Binding+Site+For+Residue+C+702'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKA OCA].  
2RKA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKA OCA].  


==Reference==
==Reference==
Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition., Stiffin RM, Sullivan SM, Carlson GM, Holyoak T, Biochemistry. 2008 Feb 19;47(7):2099-109. Epub 2008 Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18197707 18197707]
Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition., Stiffin RM, Sullivan SM, Carlson GM, Holyoak T, Biochemistry. 2008 Feb 19;47(7):2099-109. Epub 2008 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18197707 18197707]
[[Category: Phosphoenolpyruvate carboxykinase (GTP)]]
[[Category: Phosphoenolpyruvate carboxykinase (GTP)]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: nucleotide-binding]]
[[Category: nucleotide-binding]]


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