2pin: Difference between revisions

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New page: left|200px<br /><applet load="2pin" size="350" color="white" frame="true" align="right" spinBox="true" caption="2pin, resolution 2.3Å" /> '''Thyroid receptor beta...
 
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[[Image:2pin.jpg|left|200px]]<br /><applet load="2pin" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2pin.jpg|left|200px]]
caption="2pin, resolution 2.3&Aring;" />
 
'''Thyroid receptor beta in complex with inhibitor'''<br />
{{Structure
|PDB= 2pin |SIZE=350|CAPTION= <scene name='initialview01'>2pin</scene>, resolution 2.3&Aring;
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+B+501'>AC1</scene>, <scene name='pdbsite=AC2:4hy+Binding+Site+For+Residue+A+500'>AC2</scene>, <scene name='pdbsite=AC3:4hy+Binding+Site+For+Residue+B+500'>AC3</scene>, <scene name='pdbsite=AC4:Leg+Binding+Site+For+Residue+A+501'>AC4</scene> and <scene name='pdbsite=AC5:Leg+Binding+Site+For+Residue+B+502'>AC5</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene> and <scene name='pdbligand=LEG:'>LEG</scene>
|ACTIVITY=
|GENE= THRB, ERBA2, NR1A2, THR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Thyroid receptor beta in complex with inhibitor'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
2PIN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=4HY:'>4HY</scene> and <scene name='pdbligand=LEG:'>LEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+B+501'>AC1</scene>, <scene name='pdbsite=AC2:4hy+Binding+Site+For+Residue+A+500'>AC2</scene>, <scene name='pdbsite=AC3:4hy+Binding+Site+For+Residue+B+500'>AC3</scene>, <scene name='pdbsite=AC4:Leg+Binding+Site+For+Residue+A+501'>AC4</scene> and <scene name='pdbsite=AC5:Leg+Binding+Site+For+Residue+B+502'>AC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PIN OCA].  
2PIN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PIN OCA].  


==Reference==
==Reference==
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor., Estebanez-Perpina E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ, Mol Endocrinol. 2007 Dec;21(12):2919-28. Epub 2007 Sep 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17823305 17823305]
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor., Estebanez-Perpina E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ, Mol Endocrinol. 2007 Dec;21(12):2919-28. Epub 2007 Sep 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17823305 17823305]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 23: Line 32:
[[Category: SO4]]
[[Category: SO4]]
[[Category: af-2 pocket]]
[[Category: af-2 pocket]]
[[Category: aromatic-beta-amino ketones]]
[[Category: aromatic-beta-amino ketone]]
[[Category: coregulator binding]]
[[Category: coregulator binding]]
[[Category: hormone receptor]]
[[Category: hormone receptor]]
[[Category: inhibitors]]
[[Category: inhibitor]]
[[Category: nuclear receptors]]
[[Category: nuclear receptor]]
[[Category: protein-protein interactions]]
[[Category: protein-protein interaction]]
[[Category: structure-based drug design]]
[[Category: structure-based drug design]]
[[Category: surface interacting drugs]]
[[Category: surface interacting drug]]
[[Category: thyroid receptor beta]]
[[Category: thyroid receptor beta]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 27 07:59:04 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:13:26 2008''
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