4owt: Difference between revisions
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{{STRUCTURE_4owt| PDB=4owt | SCENE= }} | |||
===Structural basis of SOSS1 complex assembly=== | |||
{{ABSTRACT_PUBMED_24630995}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/INT3_HUMAN INT3_HUMAN]] Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> [[http://www.uniprot.org/uniprot/SOSSC_HUMAN SOSSC_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:19605351</ref> <ref>PMID:19683501</ref> [[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref> | |||
==About this Structure== | |||
[[4owt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWT OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024630995</ref><references group="xtra"/><references/> | |||
[[Category: Ren, W.]] | |||
[[Category: Song, H.]] | |||
[[Category: Sun, Q.]] | |||
[[Category: Tang, X.]] | |||
[[Category: Dna double-strand break]] | |||
[[Category: Homologous recombination]] | |||
[[Category: Soss1 complex]] | |||
[[Category: Ssdna- binding protein]] | |||
