1csl: Difference between revisions

Line 1:

~~{{STRUCTURE_1csl| PDB=1csl | SCENE= }}~~

==CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE==

===CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE===

~~{{ABSTRACT_PUBMED_10656783}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CSL FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [http://www.ebi.ac.uk/pdbsum/1csl PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.

~~==About this Structure==~~

The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.,Ippolito JA, Steitz TA J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783<ref>PMID:10656783</ref>

~~[[1csl]] is a 2 chain~~ structure. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1CSL OCA].~~

==~~Reference~~==

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:010656783</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

[[Category: Ippolito, J A.]]

== References ==

[[Category: Steitz, T A.]]

__TOC__

</StructureSection>

[[Category: Ippolito, J A]]

[[Category: Steitz, T A]]

[[Category: Hiv-1]]

[[Category: Rna]]

[[Category: Rre high affinity site]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-{{STRUCTURE_1csl|  PDB=1csl  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE==
-===CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE===
+<StructureSection load='1csl' size='340' side='right' caption='[[1csl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-{{ABSTRACT_PUBMED_10656783}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CSL FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [http://www.ebi.ac.uk/pdbsum/1csl PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.
-==About this Structure==
+The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.,Ippolito JA, Steitz TA J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783<ref>PMID:10656783</ref>
-[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:010656783</ref><references group="xtra"/><references/>
+</div>
-[[Category: Ippolito, J A.]]
+== References ==
-[[Category: Steitz, T A.]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ippolito, J A]]
+[[Category: Steitz, T A]]
 [[Category: Hiv-1]]
 [[Category: Rna]]
 [[Category: Rre high affinity site]]