3byz: Difference between revisions

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[[Image:3byz.jpg|left|200px]]<br /><applet load="3byz" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3byz.jpg|left|200px]]
caption="3byz, resolution 2.69&Aring;" />
 
'''2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors'''<br />
{{Structure
|PDB= 3byz |SIZE=350|CAPTION= <scene name='initialview01'>3byz</scene>, resolution 2.69&Aring;
|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Ndp+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Ndp+Binding+Site+For+Residue+C+503'>AC3</scene>, <scene name='pdbsite=AC4:Ndp+Binding+Site+For+Residue+D+504'>AC4</scene>, <scene name='pdbsite=AC5:H11+Binding+Site+For+Residue+A+601'>AC5</scene>, <scene name='pdbsite=AC6:H11+Binding+Site+For+Residue+B+602'>AC6</scene>, <scene name='pdbsite=AC7:H11+Binding+Site+For+Residue+D+603'>AC7</scene> and <scene name='pdbsite=AC8:H11+Binding+Site+For+Residue+C+604'>AC8</scene>
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=H11:'>H11</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146]
|GENE= HSD11B1, HSD11, HSD11L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors'''
 


==About this Structure==
==About this Structure==
3BYZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=H11:'>H11</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] Known structural/functional Sites: <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Ndp+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Ndp+Binding+Site+For+Residue+C+503'>AC3</scene>, <scene name='pdbsite=AC4:Ndp+Binding+Site+For+Residue+D+504'>AC4</scene>, <scene name='pdbsite=AC5:H11+Binding+Site+For+Residue+A+601'>AC5</scene>, <scene name='pdbsite=AC6:H11+Binding+Site+For+Residue+B+602'>AC6</scene>, <scene name='pdbsite=AC7:H11+Binding+Site+For+Residue+D+603'>AC7</scene> and <scene name='pdbsite=AC8:H11+Binding+Site+For+Residue+C+604'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYZ OCA].  
3BYZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYZ OCA].  
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: transmembrane]]
[[Category: transmembrane]]


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