4o06: Difference between revisions
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==1.15A Resolution Structure of the Proteasome Assembly Chaperone Nas2 PDZ Domain== | |||
<StructureSection load='4o06' size='340' side='right' caption='[[4o06]], [[Resolution|resolution]] 1.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4o06]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O06 FirstGlance]. <br> | |||
==Function== | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NAS2, YIL007C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o06 RCSB], [http://www.ebi.ac.uk/pdbsum/4o06 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PSMD9_YEAST PSMD9_YEAST]] Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). During the base subcomplex assembly is part of a NAS2:RPT4:RPT5 module; NAS2 is released during the further base assembly process. | [[http://www.uniprot.org/uniprot/PSMD9_YEAST PSMD9_YEAST]] Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC). During the base subcomplex assembly is part of a NAS2:RPT4:RPT5 module; NAS2 is released during the further base assembly process. | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific chaperones. One of these, Nas2, binds to the proteasomal AAA-ATPase subunit Rpt5. The PDZ domain of Nas2 binds to the C-terminal tail of Rpt5; however, it does not require the C-terminus of Rpt5 for binding. Here, the 1.15 A resolution structure of the PDZ domain of Nas2 is reported. This structure will provide a basis for further insights regarding the structure and function of Nas2 in proteasome assembly. | |||
1.15 A resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain.,Singh CR, Lovell S, Mehzabeen N, Chowdhury WQ, Geanes ES, Battaile KP, Roelofs J Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):418-23. doi:, 10.1107/S2053230X14003884. Epub 2014 Mar 25. PMID:24699731<ref>PMID:24699731</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Battaile, K P | == References == | ||
[[Category: Chowdhury, W Q | <references/> | ||
[[Category: Geanes, E | __TOC__ | ||
[[Category: Lovell, S | </StructureSection> | ||
[[Category: Mehzabeen, N | [[Category: Baker's yeast]] | ||
[[Category: Roelofs, J | [[Category: Battaile, K P]] | ||
[[Category: Singh, C R | [[Category: Chowdhury, W Q]] | ||
[[Category: Geanes, E]] | |||
[[Category: Lovell, S]] | |||
[[Category: Mehzabeen, N]] | |||
[[Category: Roelofs, J]] | |||
[[Category: Singh, C R]] | |||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Nas2]] | [[Category: Nas2]] | ||
[[Category: Pdz domain]] | [[Category: Pdz domain]] | ||
[[Category: Proteasome]] | [[Category: Proteasome]] | ||
Revision as of 23:11, 24 December 2014
1.15A Resolution Structure of the Proteasome Assembly Chaperone Nas2 PDZ Domain
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