Sandbox Reserved 918: Difference between revisions
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===Active Site=== | ===Active Site=== | ||
These substrates, along with many others, are cleaved by DPP IV using an active site containing a [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] composed of <scene name='57/573132/1x70_catalytictriad/ | These substrates, along with many others, are cleaved by DPP IV using an active site containing a [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] composed of <scene name='57/573132/1x70_catalytictriad/3'>Ser630, His740, and Asp708</scene>. This Serine-Histidine-Asparatate motif, best known in the enzyme [http://en.wikipedia.org/wiki/Chymotrypsin chymotrypsin], uses acid-base chemistry to facilitate the binding, cleaving, and release of the given substrate.<ref name="Gorrell"/> The mechanism of the reaction is as follows: | ||
<div style="text-align: left;"> | <div style="text-align: left;"> | ||
