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{{STRUCTURE_1vbj|  PDB=1vbj  |  SCENE=  }}
==The crystal structure of prostaglandin F synthase from Trypanosoma brucei==
===The crystal structure of prostaglandin F synthase from Trypanosoma brucei===
<StructureSection load='1vbj' size='340' side='right' caption='[[1vbj]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[1vbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VBJ FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/Q9GV41_9TRYP Q9GV41_9TRYP]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
 
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mz7|1mz7]]</td></tr>
==About this Structure==
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
[[1vbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VBJ OCA].  
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vbj RCSB], [http://www.ebi.ac.uk/pdbsum/1vbj PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vb/1vbj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Prostaglandin F synthase|Prostaglandin F synthase]]
*[[Prostaglandin F synthase|Prostaglandin F synthase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015845552</ref><references group="xtra"/><references/>
[[Category: Prostaglandin-F synthase]]
[[Category: Prostaglandin-F synthase]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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