Sandbox Reserved 186: Difference between revisions

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==Your Heading Here (maybe something like 'Structure')==
==Your Heading Here (maybe something like 'Structure')==


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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.


<scene name='58/583431/Gpx-1/1'>TextToBeDisplayed</scene>
== Overview ==
== Overview ==
Glutathione peroxidase 1 (GPx-1) is a tetramer (23 kDa per monomer) with two units composed of dimers.  GPx-1 is the most abundant member of the Glutathione peroxidase family.  It is found in all cells and is located in the cytosolic and mitochondrial compartments (1).  GPx-1 is a crucial anti-oxidant enzyme that catalyzes the conversion of hydrogen peroxide into water (2).  Interestingly GPx-1 contains the rare amino acid selenocysteine which acts as the peroxidatic residue (2).  The overall reaction that GPx-1 catalyzes is H2O2 + 2Glutathione (GSH) -> 2H20 + GS-SG  (Figure 1).  In addition to hydrogen peroxide GPx-1 can reduce other soluble hydroperoxides including lipid hydroperoxides (3).  Because of its role in regulating the intracellular concentration of reactive oxygen species, GPx-1 has been found to play a role in numerous processes including cell proliferation, apoptosis, and inflammation (1).  Furthermore deficiencies in GPx-1 has been linked to the development of cancers, neurodegenerative diseases, and heart disease (4).
Glutathione peroxidase 1 (GPx-1) is a tetramer (23 kDa per monomer) with two units composed of dimers.  GPx-1 is the most abundant member of the Glutathione peroxidase family.  It is found in all cells and is located in the cytosolic and mitochondrial compartments (1).  GPx-1 is a crucial anti-oxidant enzyme that catalyzes the conversion of hydrogen peroxide into water (2).  Interestingly GPx-1 contains the rare amino acid selenocysteine which acts as the peroxidatic residue (2).  The overall reaction that GPx-1 catalyzes is H2O2 + 2Glutathione (GSH) -> 2H20 + GS-SG  (Figure 1).  In addition to hydrogen peroxide GPx-1 can reduce other soluble hydroperoxides including lipid hydroperoxides (3).  Because of its role in regulating the intracellular concentration of reactive oxygen species, GPx-1 has been found to play a role in numerous processes including cell proliferation, apoptosis, and inflammation (1).  Furthermore deficiencies in GPx-1 has been linked to the development of cancers, neurodegenerative diseases, and heart disease (4).
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