4pz3: Difference between revisions

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'''Unreleased structure'''
==High-resolution crystal structure of the human CD44 hyaluronan binding domain complex with undefined peptides==
<StructureSection load='4pz3' size='340' side='right' caption='[[4pz3]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4pz3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PZ3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uuh|1uuh]], [[4pz4|4pz4]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pz3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pz3 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Two new crystal structures of the extracellular hyaluronan-binding domain of human CD44 are described at high resolution. A hexagonal crystal form at 1.60 A resolution and a monoclinic form at 1.08 A resolution both have two molecules in the asymmetric unit arranged about a similar noncrystallographic twofold axis of symmetry. These structures are compared with those previously reported at 2.20 A resolution to show that the fold is quite resistant to structural deformation in different crystal environments. Unexpectedly, a short peptide is found in the monoclinic crystals at a site remote from the known hyaluronan-binding groove. The peptide with a valine at the carboxy-terminus must have co-purified from the bacterial expression host and binds on the opposite side of the domain from the known hyaluronan-binding groove. This opportunistic binding may identify a site of interaction used as CD44 assembles with other proteins to accomplish effective signaling regarding changes to the extracellular environment.


The entry 4pz3 is ON HOLD  until Paper Publication
High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction.,Liu LK, Finzel B Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884<ref>PMID:25195884</ref>


Authors: Liu, L.K., Finzel, B.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: High-resolution crystal structure of the human CD44 hyaluronan binding domain complex with undefined peptides
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Finzel, B.]]
[[Category: Liu, L K.]]
[[Category: Binding protein]]
[[Category: Cell adhesion]]
[[Category: Ectodomain]]
[[Category: Hyaluronan]]
[[Category: Link module]]
Retrieved from "https://proteopedia.org/4pz3"