2hrm: Difference between revisions

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[[Image:2hrm.jpg|left|200px]]<br /><applet load="2hrm" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hrm.jpg|left|200px]]
caption="2hrm, resolution 1.70&Aring;" />
 
'''Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP'''<br />
{{Structure
|PDB= 2hrm |SIZE=350|CAPTION= <scene name='initialview01'>2hrm</scene>, resolution 1.70&Aring;
|SITE= <scene name='pdbsite=AC1:Uc5+Binding+Site+For+Residue+A+777'>AC1</scene> and <scene name='pdbsite=AC2:Edo+Binding+Site+For+Residue+A+301'>AC2</scene>
|LIGAND= <scene name='pdbligand=UC5:2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE'>UC5</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23]
|GENE= dut ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HRM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=UC5:'>UC5</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] Known structural/functional Sites: <scene name='pdbsite=AC1:Uc5+Binding+Site+For+Residue+A+777'>AC1</scene> and <scene name='pdbsite=AC2:Edo+Binding+Site+For+Residue+A+301'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRM OCA].  
2HRM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRM OCA].  


==Reference==
==Reference==
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site., Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG, Proteins. 2008 Apr;71(1):308-19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17932923 17932923]
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site., Kovari J, Barabas O, Varga B, Bekesi A, Tolgyesi F, Fidy J, Nagy J, Vertessy BG, Proteins. 2008 Apr;71(1):308-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932923 17932923]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: jelly roll]]
[[Category: jelly roll]]


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