Proton Channels: Difference between revisions
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In January, 2008, crystallographic and NMR structures were published side by side for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. | In January, 2008, crystallographic and NMR structures were published side by side for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. | ||
At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel. | At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel. (Controls for animating this morph are under development.) | ||
