Sandbox 123: Difference between revisions
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<scene name='36/365380/3zfz_1/3'>PBP2a in complex with Ceftaroline</scene> (PDB:3ZFZ) | <scene name='36/365380/3zfz_1/3'>PBP2a in complex with Ceftaroline</scene> (PDB:3ZFZ) | ||
In addition to TP domain of PBP2a, there is an allosteric domain,highlighted orange, in which the distance between | In addition to TP domain of PBP2a, there is an allosteric domain,highlighted orange, in which the distance between <scene name='36/365380/3zfz_1/15'>the active site and the allosteric site</scene> is 60Å. | ||
<scene name='36/365380/3zfz_1/15'>the active site and the allosteric site</scene> is 60Å. | |||
Allosteric site serves as a binding site for the substrate <scene name='36/365380/3zfz_1/7'>peptidoglycan</scene>. When the substrate binds to the | Allosteric site serves as a binding site for the substrate <scene name='36/365380/3zfz_1/7'>peptidoglycan</scene>. When the substrate binds to the <scene name='36/365380/3zfz_1/8'>allosteric site</scene> (Tyr105, Asn146, Asp295, Tyr297), a conformational change occurs at the active site, opening it and allowing catalytic action to occur. | ||
<scene name='36/365380/3zfz_1/8'>allosteric site</scene> (Tyr105, Asn146, Asp295, Tyr297), a conformational change occurs at the active site, opening it and allowing catalytic action to occur. | |||
The medicine, <scene name='36/365380/3zfz_1/12'>ceftaroline</scene>, mimics the substrate at the allosteric site opening the active site, allowing ceftaroline to <scene name='36/365380/3zfz_1/14'>enter and bind noncovalently</scene>. | The medicine, <scene name='36/365380/3zfz_1/12'>ceftaroline</scene>, mimics the substrate at the allosteric site opening the active site, allowing ceftaroline to <scene name='36/365380/3zfz_1/14'>enter and bind noncovalently</scene>. | ||
