Sandbox Reserved 7: Difference between revisions
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== The structure of the catalytic subunit of telomerase bound to its RNA template and telomeric DNA == | == The structure of the catalytic subunit of telomerase bound to its RNA template and telomeric DNA == | ||
Telomerase Reverse Transcriptase (TERT) is involved in catalyzing the extension of telomeres in eukaryotic DNA. Telomeres are repetitive sequences of nucleotides at the end of eukaryotic DNA which limit the erosion of the genome during DNA replication. | |||
* TERT activity has been found to be activated by magnesium, and the short-term deficiency of magnesium in all chambers of the heart, and smooth muscle in animals has been shown to down-regulate telomerase activity<ref>1</ref>. Here, the contacts between the magnesium ion and each of the two chains in 3KYL is shown. | |||
