Sandbox Reserved 932: Difference between revisions

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=== Denmotoxin belongs to a family of non-conventional three-finger toxins ===

Three-finger toxins (3FTXs) are the most common family of snake venom proteins; these venoms can be found in elapid, colubrid and hydrophiid snakes and include toxins such as α-cobratoxin and α-bungarotoxin. 3FTXs are non-enzymatic proteins which form a structurally conserved superfamily whose members all share a highly conserved structure. The core structure of 3FTXs is formed by <scene name='57/579702/Three_fingers/1'>three β-stranded polypeptide loops</scene> joined together by four conserved disulphide bridges located in the <scene name='57/579702/3ftx_beta_strands/2'>core</scene> of the protein. Despite the similarities in the structure of different toxins belonging to the family, the 3FTXs from various venoms have a variety of receptors/acceptors and exhibit differential responses in their targets. The members of the family can vary slightly in the length and type of twists of the tree loops.

Three-finger toxins (3FTXs) are the most common family of snake venom proteins; these venoms can be found in elapid, colubrid and hydrophiid snakes and include toxins such as α-cobratoxin and α-bungarotoxin. 3FTXs are non-enzymatic proteins which form a structurally conserved superfamily whose members all share a highly conserved structure. The core structure of 3FTXs is formed by three <scene name='57/579702/Three_fingers/1'>three β-stranded polypeptide loops</scene> joined together by four conserved disulphide bridges located in the <scene name='57/579702/3ftx_beta_strands/2'>core</scene> of the protein. Despite the similarities in the structure of different toxins belonging to the family, the 3FTXs from various venoms have a variety of receptors/acceptors and exhibit differential responses in their targets. The members of the family can vary slightly in the length and type of twists of the tree loops.

Denmotoxin shares approximately 30% sequence similarity with other 3FTXs with an exception of exhibiting approximately 50% sequence similarity with another colubrid snake venom α-colubritoxin. Despite the relatively low sequence similarity, denmotoxin possesses all the residues needed to maintain the 3 finger fold. A large part of the sequence similarity between denmotoxin and other 3FTXs is due to the highly conserved disulphides and a number of structurally important residues.

Sandbox Reserved 932: Difference between revisions

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 === Denmotoxin belongs to a family of non-conventional three-finger toxins ===
-Three-finger toxins (3FTXs) are the most common family of snake venom proteins; these venoms can be found in elapid, colubrid and hydrophiid snakes and include toxins such as α-cobratoxin and α-bungarotoxin. 3FTXs are  non-enzymatic proteins which form a structurally conserved superfamily whose members all share a highly conserved structure. The core structure of 3FTXs is formed by <scene name='57/579702/Three_fingers/1'>three β-stranded polypeptide loops</scene> joined together by four conserved disulphide bridges located in the <scene name='57/579702/3ftx_beta_strands/2'>core</scene> of the protein. Despite the similarities in the structure of different toxins belonging to the family, the 3FTXs from various venoms have a variety of receptors/acceptors and exhibit differential responses in their targets. The members of the family can vary slightly in the length and type of twists of the tree loops.
+Three-finger toxins (3FTXs) are the most common family of snake venom proteins; these venoms can be found in elapid, colubrid and hydrophiid snakes and include toxins such as α-cobratoxin and α-bungarotoxin. 3FTXs are  non-enzymatic proteins which form a structurally conserved superfamily whose members all share a highly conserved structure. The core structure of 3FTXs is formed by three <scene name='57/579702/Three_fingers/1'>three β-stranded polypeptide loops</scene> joined together by four conserved disulphide bridges located in the <scene name='57/579702/3ftx_beta_strands/2'>core</scene> of the protein. Despite the similarities in the structure of different toxins belonging to the family, the 3FTXs from various venoms have a variety of receptors/acceptors and exhibit differential responses in their targets. The members of the family can vary slightly in the length and type of twists of the tree loops.
 Denmotoxin shares approximately 30% sequence similarity with other 3FTXs with an exception of exhibiting approximately 50% sequence similarity with another colubrid snake venom α-colubritoxin. Despite the relatively low sequence similarity, denmotoxin possesses all the residues needed to maintain the 3 finger fold. A large part of the sequence similarity between denmotoxin and other 3FTXs is due to the highly conserved disulphides and a number of structurally important residues.