2mk2: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MK2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MK2 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INPPL1, SHIP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">INPPL1, SHIP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.86 3.1.3.86] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-3,4,5-trisphosphate_5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.86 3.1.3.86] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mk2 RCSB], [http://www.ebi.ac.uk/pdbsum/2mk2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mk2 RCSB], [http://www.ebi.ac.uk/pdbsum/2mk2 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/SHIP2_HUMAN SHIP2_HUMAN]] Defects in INPPL1 may be a cause of susceptibility to type 2 diabetes mellitus non-insulin dependent (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:12086927</ref> <ref>PMID:15687335</ref> Note=Genetic variations in INPPL1 may be a cause of susceptibility to metabolic syndrome. Metabolic syndrome is characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent. | [[http://www.uniprot.org/uniprot/SHIP2_HUMAN SHIP2_HUMAN]] Defects in INPPL1 may be a cause of susceptibility to type 2 diabetes mellitus non-insulin dependent (NIDDM) [MIM:[http://omim.org/entry/125853 125853]].<ref>PMID:12086927</ref> <ref>PMID:15687335</ref> Note=Genetic variations in INPPL1 may be a cause of susceptibility to metabolic syndrome. Metabolic syndrome is characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent. | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase]] | [[Category: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase]] | ||
[[Category: Everett, J K | [[Category: Everett, J K]] | ||
[[Category: Janjua, H | [[Category: Janjua, H]] | ||
[[Category: Kennedy, M A | [[Category: Kennedy, M A]] | ||
[[Category: Montelione, G T | [[Category: Montelione, G T]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Ramelot, T A | [[Category: Ramelot, T A]] | ||
[[Category: Xiao, R | [[Category: Xiao, R]] | ||
[[Category: Yang, Y | [[Category: Yang, Y]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
