3m3w: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3m3w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3W FirstGlance]. <br> | <table><tr><td colspan='2'>[[3m3w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M3W FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3w RCSB], [http://www.ebi.ac.uk/pdbsum/3m3w PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m3w RCSB], [http://www.ebi.ac.uk/pdbsum/3m3w PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PACN3_MOUSE PACN3_MOUSE]] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The rigidity of the wedge loop in PACSIN 3 is a key factor in dictating the diameters of tubules.,Bai X, Meng G, Luo M, Zheng X J Biol Chem. 2012 May 9. PMID:22573331<ref>PMID:22573331</ref> | The rigidity of the wedge loop in PACSIN 3 is a key factor in dictating the diameters of tubules.,Bai X, Meng G, Luo M, Zheng X J Biol Chem. 2012 May 9. PMID:22573331<ref>PMID:22573331</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Bai, X Y | [[Category: Bai, X Y]] | ||
[[Category: Meng, G | [[Category: Meng, G]] | ||
[[Category: Bar domain]] | [[Category: Bar domain]] | ||
[[Category: Endocytosis]] | [[Category: Endocytosis]] | ||
[[Category: Mouse]] | [[Category: Mouse]] | ||
[[Category: Pacsin3]] | [[Category: Pacsin3]] | ||
