4c56: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==X-ray structure of the complex between staphylococcal enterotoxin B, T cell receptor and major histocompatibility complex class II==

== Structural highlights ==

<table><tr><td colspan='2'>[[4c56]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C56 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c56 RCSB], [http://www.ebi.ac.uk/pdbsum/4c56 PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Superantigens are immune-stimulatory toxins produced by Staphylococcus aureus, which are able to interact with host immune receptors to induce a massive release of cytokines, causing toxic shock syndrome and possibly death. In this article, we present the x-ray structure of staphylococcal enterotoxin B (SEB) in complex with its receptors, the TCR and MHC class II, forming a ternary complex. The structure, in combination with functional analyses, clearly shows how SEB adopts a wedge-like position when binding to the beta-chain of TCR, allowing for an interaction between the alpha-chain of TCR and MHC. Furthermore, the binding mode also circumvents contact between TCR and the peptide presented by MHC, which enables SEB to initiate a peptide-independent activation of T cells.

~~The entry 4c56 is ON HOLD until Paper Publication~~

Structure of the Superantigen Staphylococcal Enterotoxin B in Complex with TCR and Peptide-MHC Demonstrates Absence of TCR-Peptide Contacts.,Rodstrom KE, Elbing K, Lindkvist-Petersson K J Immunol. 2014 Jul 11. pii: 1401268. PMID:25015819<ref>PMID:25015819</ref>

~~Authors: Rodstrom~~, K.E.J., Elbing, K., Lindkvist-Petersson, K.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: X-~~ray structure of the complex between staphylococcal enterotoxin B, T cell receptor and major histocompatibility~~ complex ~~class II~~

== References ==

__TOC__

</StructureSection>

[[Category: Elbing, K.]]

[[Category: Lindkvist-Petersson, K.]]

[[Category: Rodstrom, K E.J.]]

[[Category: Immune system-toxin complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==X-ray structure of the complex between staphylococcal enterotoxin B, T cell receptor and major histocompatibility complex class II==
+<StructureSection load='4c56' size='340' side='right' caption='[[4c56]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4c56]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C56 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c56 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c56 RCSB], [http://www.ebi.ac.uk/pdbsum/4c56 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Superantigens are immune-stimulatory toxins produced by Staphylococcus aureus, which are able to interact with host immune receptors to induce a massive release of cytokines, causing toxic shock syndrome and possibly death. In this article, we present the x-ray structure of staphylococcal enterotoxin B (SEB) in complex with its receptors, the TCR and MHC class II, forming a ternary complex. The structure, in combination with functional analyses, clearly shows how SEB adopts a wedge-like position when binding to the beta-chain of TCR, allowing for an interaction between the alpha-chain of TCR and MHC. Furthermore, the binding mode also circumvents contact between TCR and the peptide presented by MHC, which enables SEB to initiate a peptide-independent activation of T cells.
-The entry 4c56 is ON HOLD  until Paper Publication
+Structure of the Superantigen Staphylococcal Enterotoxin B in Complex with TCR and Peptide-MHC Demonstrates Absence of TCR-Peptide Contacts.,Rodstrom KE, Elbing K, Lindkvist-Petersson K J Immunol. 2014 Jul 11. pii: 1401268. PMID:25015819<ref>PMID:25015819</ref>
-Authors: Rodstrom, K.E.J., Elbing, K., Lindkvist-Petersson, K.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: X-ray structure of the complex between staphylococcal enterotoxin B, T cell receptor and major histocompatibility complex class II
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Elbing, K.]]
+[[Category: Lindkvist-Petersson, K.]]
+[[Category: Rodstrom, K E.J.]]
+[[Category: Immune system-toxin complex]]