4q93: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Resveratrol bound at the active site of human tyrosyl tRNA synthetase==

~~The~~ entry ~~4q93~~ is ~~ON HOLD~~ ~~until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q93 FirstGlance].

~~Authors~~: Mathew, S., Schimmel, P.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[1q11|1q11]], [[1n3l|1n3l]], [[4qbt|4qbt]]</td></tr>

~~Description~~: Resveratrol ~~bound at the active site of human tyrosyl tRNA synthetase~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[http://omim.org/entry/608323 608323]]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>

== Function ==

[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Tyrosine--tRNA ligase]]

[[Category: Mathew, S]]

[[Category: Schimmel, P]]

[[Category: Active site]]

[[Category: Amino acid activation]]

[[Category: Aminoacyl trna synthetase]]

[[Category: Ligase]]

[[Category: Resveratrol]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Resveratrol bound at the active site of human tyrosyl tRNA synthetase==
+<StructureSection load='4q93' size='340' side='right' caption='[[4q93]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-The entry 4q93 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4q93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q93 FirstGlance]. <br>
-Authors: Mathew, S., Schimmel, P.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q11|1q11]], [[1n3l|1n3l]], [[4qbt|4qbt]]</td></tr>
-Description: Resveratrol bound at the active site of human tyrosyl tRNA synthetase
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q93 RCSB], [http://www.ebi.ac.uk/pdbsum/4q93 PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC) [MIM:[http://omim.org/entry/608323 608323]]. CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.<ref>PMID:16429158</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/SYYC_HUMAN SYYC_HUMAN]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Tyrosine--tRNA ligase]]
+[[Category: Mathew, S]]
+[[Category: Schimmel, P]]
+[[Category: Active site]]
+[[Category: Amino acid activation]]
+[[Category: Aminoacyl trna synthetase]]
+[[Category: Ligase]]
+[[Category: Resveratrol]]