4bli: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bli]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLI FirstGlance]. <br> | <table><tr><td colspan='2'>[[4bli]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BLI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BLI FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMK:(3-DEOXY-3-(3-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(3-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>GMK</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMK:(3-DEOXY-3-(3-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(3-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>GMK</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4blj|4blj]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4blj|4blj]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bli RCSB], [http://www.ebi.ac.uk/pdbsum/4bli PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bli OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bli RCSB], [http://www.ebi.ac.uk/pdbsum/4bli PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Engstrom, O | [[Category: Engstrom, O]] | ||
[[Category: Hakansson, M | [[Category: Hakansson, M]] | ||
[[Category: Leffler, H | [[Category: Leffler, H]] | ||
[[Category: Logan, D T | [[Category: Logan, D T]] | ||
[[Category: Nilsson, U J | [[Category: Nilsson, U J]] | ||
[[Category: Noresson, A L | [[Category: Noresson, A L]] | ||
[[Category: Oberg, C T | [[Category: Oberg, C T]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 18:56, 24 December 2014
Galectin-3c in complex with Bisamido-thiogalactoside derivate 1
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