3epw: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3epw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_vivax Trypanosoma vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EPW FirstGlance]. <br> | <table><tr><td colspan='2'>[[3epw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_vivax Trypanosoma vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EPW FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=JMQ:7-(((2R,3R,4S)-3,4-DIHYDROXY-2-(HYDROXYMETHYL)PYRROLIDIN-1-YL)METHYL)-3H-PYRROLO[3,2-D]PYRIMIDIN-4(5H)-ONE'>JMQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=JMQ:7-(((2R,3R,4S)-3,4-DIHYDROXY-2-(HYDROXYMETHYL)PYRROLIDIN-1-YL)METHYL)-3H-PYRROLO[3,2-D]PYRIMIDIN-4(5H)-ONE'>JMQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ff2|2ff2]], [[1hoz|1hoz]], [[1hp0|1hp0]], [[1kic|1kic]], [[3b9g|3b9g]], [[3epx|3epx]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ff2|2ff2]], [[1hoz|1hoz]], [[1hp0|1hp0]], [[1kic|1kic]], [[3b9g|3b9g]], [[3epx|3epx]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine_nucleosidase Purine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.1 3.2.2.1] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3epw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3epw RCSB], [http://www.ebi.ac.uk/pdbsum/3epw PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3epw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3epw RCSB], [http://www.ebi.ac.uk/pdbsum/3epw PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.,Versees W, Goeminne A, Berg M, Vandemeulebroucke A, Haemers A, Augustyns K, Steyaert J Biochim Biophys Acta. 2009 Jun;1794(6):953-60. Epub 2009 Mar 10. PMID:19281874<ref>PMID:19281874</ref> | Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.,Versees W, Goeminne A, Berg M, Vandemeulebroucke A, Haemers A, Augustyns K, Steyaert J Biochim Biophys Acta. 2009 Jun;1794(6):953-60. Epub 2009 Mar 10. PMID:19281874<ref>PMID:19281874</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Trypanosoma vivax]] | [[Category: Trypanosoma vivax]] | ||
[[Category: Augustyns, K]] | [[Category: Augustyns, K]] | ||
[[Category: Berg, M | [[Category: Berg, M]] | ||
[[Category: Goeminne, A | [[Category: Goeminne, A]] | ||
[[Category: Haemers, A | [[Category: Haemers, A]] | ||
[[Category: Steyaert, J | [[Category: Steyaert, J]] | ||
[[Category: Vandemeulebroucke, A | [[Category: Vandemeulebroucke, A]] | ||
[[Category: Versees, W | [[Category: Versees, W]] | ||
[[Category: Active site loop]] | [[Category: Active site loop]] | ||
[[Category: Aromatic stacking]] | [[Category: Aromatic stacking]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
Revision as of 23:09, 3 January 2015
Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
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